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Reactivity | Human Mouse Rat |
Tested applications | WB IHC IF IP FC |
Recommended Dilution | WB 1:500 - 1:2000 IHC 1:20 - 1:200 IF 1:20 - 1:100 IP 1:20 - 1:50 FC 1:20 - 1:50 |
Calculated MW | 40kDa |
Observed MW | Refer to figures |
Immunogen | Recombinant protein of human ATP6V0D1 |
Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Synonym | P39; VATX; VMA6; ATP6D; ATP6DV; VPATPD; |
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is known as the D subunit and is found ubiquitously.
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