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Reactivity | Human Mouse Rat |
Tested applications | WB IP |
Recommended Dilution | WB 1:500 - 1:2000 IP 1:20 - 1:100 |
Calculated MW | 42kDa |
Observed MW | Refer to Figures |
Immunogen | Recombinant protein of human HDAC8 |
Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Concentration | fp |
Synonym | HD8; WTS; RPD3; CDA07; CDLS5; MRXS6; HDACL1; |
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene.
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