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Reactivity | Human |
Tested applications | WB IHC |
Recommended Dilution | WB 1:1000 - 1:2000 IHC 1:50 - 1:200 |
Calculated MW | 37kDa |
Observed MW | Refer to figures |
Immunogen | Recombinant protein of human NFYA |
Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Synonym | HAP2; CBF-A; CBF-B; NF-YA; |
The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms.
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