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Reactivity | Human Mouse |
Tested applications | WB IHC IF |
Recommended Dilution | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:20 - 1:50 |
Calculated MW | 122kDa |
Observed MW | Refer to figures |
Immunogen | A synthetic peptide of human HDAC5 |
Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Concentration | fp |
Synonym | HD5; NY-CO-9; |
Western blot analysis of extracts of various cell lines, using HDAC5 antibody.
Western blot analysis of extracts of various cell lines, using HDAC5 antibody.
Immunohistochemistry of paraffin-embedded Human mammary gland using HDAC5 antibody at dilution of 1:100 (x40 lens).
Immunohistochemistry of paraffin-embedded Mouse lung using HDAC5 antibody at dilution of 1:100 (x40 lens).
Immunohistochemistry of paraffin-embedded Mouse lung using HDAC5 antibody at dilution of 1:100 (x40 lens).
Immunofluorescence analysis of A549 cell using HDAC5 antibody. Blue: DAPI for nuclear staining.
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.
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