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Reactivity | Human Mouse Rat |
Tested applications | WB IHC |
Recommended Dilution | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
Calculated MW | 78kDa |
Observed MW | Refer to figures |
Immunogen | Recombinant protein of human UVRAG |
Storage Buffer | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Synonym | p63; DHTX; VPS38; |
Immunohistochemistry of paraffin-embedded human liver injury using UVRAG antibody at dilution of 1:100 (x40 lens).
Immunohistochemistry of paraffin-embedded rat lung using UVRAG antibody at dilution of 1:100 (x40 lens).
Immunohistochemistry of paraffin-embedded mouse lung using UVRAG antibody at dilution of 1:100 (x40 lens).
This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer.
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